Sosie Bacon, who plays Brenda's niece Charlie, is Kyra Sedgwick's real-life daughter to Kevin Bacon. They previously acted together in Loverboy (2005).
Kyra Sedgwick submitted this episode for consideration after she was nominated for Outstanding Lead Actress in a Drama Series at the Primetime Emmy Awards. She subsequently won the award for the first time.
During a hospital scene between Brenda , Charlie and Fritz, Fritz say to Brenda about Charlie, "You two are so related." In real life Kyra and Sosie are mother and daughter.
Charlie expressing exasperation that neither Brenda nor Fritz understand her use of pot and saying that they've tried it too lacks understanding. Brenda previously being with the CIA and other police departments as well as Fritz's FBI employment would never have used pot or any other illegal substances. Both would potentially be subject to random drug tests, and both CIA and FBI employment would be barred for any illegal drug use.