Brian and Stewie are the only characters featured in this episode and both are voiced by Seth MacFarlane. Hence, MacFarlane is the only actor with dialogue and the entirety of the episode consists of him talking to himself.
This episode contains no cut-away gags, a rarity for Family Guy since most of its jokes are based around their signature cut-aways
First episode to take place in one setting over the entire runtime
There isn't a single piece of music in the episode, not even the show's opening theme.
The initial broadcast of this episode on Fox included a scene before the episode fully began with Stewie and Brian explaining that audiences were going to be seeing a different kind of story, and ended with a musical number between Stewie and Brian over the closing credits. In syndication, these scenes have almost always been cut so that the somber, music-less tone of the main plot is carried over for the entire episode.