As Judas was paid with 30 pieces of silver, Sheldon slaps down a tray with 30 pieces of silverware in front of Leonard.
The melody Sheldon plays on his recorder is Morgenstemning (Morning Mood) by the Norwegian composer Edvard Grieg, from Peer Gynt Suite No. 1, op. 46.
The hotel room number is 714. This is also the street number of the Conner home in "Roseanne", a show in which Johnny Galecki (Leonard) co-starred for many years.
Title reference: CERN's headquarters in Switzerland, which Leonard has been invited to visit, is the home of the Large Hadron Collider, the particle smasher which led to the discovery of the Higgs Boson.
The Professor Norton that Leonard replaces in representing Cal Tech at CERN is fictitious. No Cal Tech Nobel Laurates were named Norton. There was a scientific Nobel Laurate named Edward Norton Lorenz. However, he was a Cambridge professor who died in 2008 at age 90.