Hugh Laurie makes his American television directorial debut in this episode. He also directed The C Word (2012).
The Latin phrase on a poster on the wall means "Everyone loves you when you're about to die."
House's personnel file indicates that his physician and emergency contact are both Wilson.
Jennifer Morrison and Jesse Spencer were together in real life. After they met on their way to film the pilot and dated throughout the first three seasons, they became engaged halfway through season three but broke up shortly before season four. Hugh Laurie noted that he shed a tear as Cameron tells Chase she isn't sure she ever loved him.
Per his file that Foreman finds in the archives, Taub's full name is Christopher Michael Taub.