When Dean is lulling the baby to sleep in the motel room, he is humming Deep Purple's "Smoke on the Water". That same song is playing during the final scene of the episode.
The baby's name, "Bobby John", references the boys' friend, Bobby, and their father, John Winchester
The security systems installed in the houses of the victims is from Harper Caine Security. In the show Two and a Half Men (2003) the last name of the brothers is 'Harper'.
The title of the episode is a clear reference to the CBS sitcom of the same name, which follows a rich uncle who takes in his brother and nephew and the mishaps that follow.