The code Sheldon uses to activate the "self destruct" sequence on his laptop, 1-1-A-2-B, is the code used by Spock in the Star Trek episode Let That Be Your Last Battlefield (1969). The layout of the program he is using for the countdown is similar to the designs of the computer screens seen first in Star Trek: The Next Generation (1987).
The waltz that Sheldon la-la's to the taxi driver is The Blue Danube Waltz by Johann Strauss the Younger.
After kissing Amy for the first time, Sheldon says "fascinating." This is the catchphrase of his idol, Spock from Star Trek the Original Series.