Heavy Duty is recruited by Flint to help bring in his cousin Roadblock; unfortunately for both men and the Joes, Major Bludd is seeking vengeance for the scars received in their last encounter.
Investigating a missing kid from Tunnel Rat's old neighborhood, the Joes head to Brooklyn, where they discover an urban legend about a monster in the sewers may in fact be true.
The Joes infiltrate a global telecommunications conference hosted by the Baroness at her ancestral castle. There, they uncover a Cobra plot to enslave the world via cell phones, while meeting an unexpected ally.
On a mission to capture Mindbender, the Joes become entranced and are trapped in a cult-like commune run by the eerily charismatic twin brothers Tomax and Xamot.
The Joes raid a Cobra medical facility looking for information on the alleged inhumane experimentations being conducted as well as a mysterious 'Patient X'.