J. Jonah Jameson is voiced by JK Simmons who previously played the same character in the live action Spider-Man movies (2002)
When the show was renewed for a fourth season of 26 episodes, that brought the total episode count to 104 episodes. This makes Ultimate Spider-Man not only the longest running Spider-Man series (surpassing the '90s animated Spider-Man that ran for 65 episodes), but also the longest running series ever based off a Marvel comic (surpassing the '90s animated X-Men which ran for 76 episodes). It's even the longest running show Marvel has ever been associated with surpassing '80s shows like G.I. Joe and The Transformers (which ran for 95 and 98 episodes respectively).
At the 2011 San Diego Comic Con, it was confirmed that Clark Gregg would provide the voice of S.H.I.E.L.D. Agent Phil Coulson, the same character Gregg has played in the Marvel Cinematic Universe movies released by Marvel Studios, including both Iron Man (2008) movies, Thor (2011), The Avengers (2012) and agents of shield(2013)
Drake Bell, who provides the voice of Spider-Man in this series, also starred in Superhero Movie (2008), a parody movie based on the Sam Raimi Spider-Man Series.
Ultimate Spider-Man is loosely based on the comic book series of the same name written by Brian Michael Bendis.