This episode is part of a three part crossover event, Night of the Hurricane, across all Seth MacFarlane shows:
- Part 1: The Hurricane (2011)
- Part 2: Seahorse Seashell Party (2011)
- Part 3: Hurricane! (2011)
The name of the episode "Seahorse Seashell Party" is a reference to a popular YouTube video called "Lizard on Acid" about a man on acid who talks about various images such as seashells and seahorses, much like what Brian sees in the episode.
When Stewie tells Brian to "return the map" during his hallucination, and Brian runs into and pushes the wall further into itself, is a reference and scene from the movie Time Bandits (1981).
The visuals of Brian's hallucination are inspired by the famous painting "Dulle Griet" of Pieter Bruegel the Elder. Dulle Griet is called Mad Meg in English, which is an obvious reference to Meg's outburst in this episode.
Except for flashbacks the entire episode takes place only at the Griffins house due to the hurricane.