Though this episode is entitled Nebraska, the American Gothic scene recreated by the pull-back shot immediately following Dexter's first roadtrip kill features the Dibble House, in Eldon, Iowa.
Kearney is the fifth most populous city of Nebraska, with a population of 30,787 individuals. It is the county seat of the Buffalo County. It is home to the University of Nebraska at Kearney.
Scott Michael Campbell (Norm, the motel clerk) is growing cannabis. He also appears doing the same in House (2004) Euphoria: Part 1 (2006) (as Joe Luria).
At 36:50 Dexter and is imaginary dead brother are standing in front of a lawn mower ad, with gothic windows. Dexter is holding a pitchfork. It's meant to reference the classic painting "American Gothic" by Grant Wood.
In response to Dexter saying he would go to Portland, Oregon, Dexter's dark passenger brother (Christian Camargo) says "That's a little predictable isn't it? Isn't that where all serial killers go?". This is in reference to the following serial killers, who at some point were active in Portland, Oregon: Gary Ridgway (The Green River Killer), Keith Hunter Jesperson (The Happy Face Killer), Sebastian Shaw, Andrew David Edwards, William Perry Jackson, Richard Laurence Marquette, Randall Woodfield (The I-5 Bandit), Cesar Barone, Scott William Cox, Thomas Creech, Jeffrey Paul Cutlip, John Fautenberry, Levi Boone Helm (The Kentucky Cannibal), Homer Lee Jackson III, Randy Kraft (The Freeway Killer/Scorecard Killer), Gerald "Jerry" Walter McFadden (The Animal), Earle Nelson (The Dark Strangler), Todd Alan Reed (The Forest Park Killer), Robert Joseph Silveria Jr (The Boxcar Killer), Edward Bates Soper, Edward Delon Warren, Douglas Franklin Wright.