The missing little girl's backpack has the initials "R.H." for Robin Howell. This can also signify "Riding Hood" for Little Red Riding Hood. She was also on the way to her Grandfather's house (just like on her way to Grandmother's house). She even went "over the river and through the woods."
The basis for this episode and the origin of the opening quote comes from "Little Red Riding Hood" first written down by Charles Perrault.
Opens with the quote '"The wolf thought to himself, what tender young creature. What a nice plump mouthful..." The Brothers Grimm 1812'.
Nick asks Monroe about silver bullets in regards to dealing with the postman, a Blutbad; in folklore, silver bullets are often the only way to effectively kill or go up against a werewolf, witch, or other monsters. The idea of the werewolf's supposed vulnerability to silver most likely dates back to the legend of the Beast of Gévaudan, in which a gigantic wolf is killed by a hunter wielding a gun loaded with silver bullets. The hunter's name is also Argent, which is Latin for silver. Even in the Brothers Grimm fairy-tales, there is some mythology regarding silver bullets. For instance, in The Two Brothers, a bullet-proof witch is shot down by silver bullets.
The song on Sylvie Oster's iPod is "Sweet Dreams" by Eurythmics. At the end of the episode, the cover of this song by Marilyn Manson is played. Also, according to the script, the song was originally going to be "Once Upon a Time (In Your Wildest Dreams)" by Moody Blues.