When Dean sees the betting record with future information, he remarks "He's using the Biff strategy!" This refers to Biff Tannen from Back to the Future Part II (1989) who uses 21st century sports almanac to place winning bets on horse races in 1955.
Chronos/Chronus is a deity in Greek mythology, a personification of time. He is at times identified with the similarly named Titan, Kronos/Cronus, the God of the Harvest.
Nicholas Lea, who plays Elliot Ness was an important character in The X-Files (1993). Many other actors from Supernatural, including Mitch Pileggi (Samuel Cambell) previously starred on that show.
Seventh episode to not feature the Impala. Sixth episode in a row to not feature it.
Linda Darlow, who plays Ezra Moore, returns in Twigs & Twine & Tasha Banes (Season 12, Episode 20) as the Demon Borrower Witch.