This is the first time Crowley calls Dean Squirrel.
Tyler Johnston, introduced in this episode as Samandriel, was also in Season 1, Ep. 8 Bugs (2005), playing Matt Pike.
Sam and Dean's FBI aliases, Neil and Sixx, refered to Nikki Sixx and Vince Neil, members of the rock band Mötley Crüe.
The auction takes place in room 101, an allusion to the torture room in Orwell's 1984.
This is the first episode in which an exorcism is recited in reverse in order to prevent a demon from "smoking out."