Following the incident caused by the Agents of C.R.A.S.H., the Agents of S.M.A.S.H. get transported to Skaar's home planet Sakaar where they must stop Leader from controlling the entire planet and the Agents of S.M.A.S.H. themselves.
While escorting Abomination to stand trial for his crimes, the Hulks run into Ghost Rider, who has come to make both Abomination and Red atone for their past bad deeds.
Hulk follows Leader back in time to the Viking Era and teams up with young Thor and Loki. The Agents of S.M.A.S.H. fight to stop "All Father" Leader from taking over the planet.
Hulk begrudgingly teams up with The Thing to take the fight to the Leader's doorstep when his arch nemesis puts the lives of the Agents of S.M.A.S.H. on the line.