The song "Eyes on Fire" plays near the start of this episode. It also appears in the movie Twilight (2008), which also has a vampire theme.
Guest star Adina Porter played a recurring character on True Blood (2008), another vampire-themed show, which started a year before The Vampire Diaries.
"Bourbon Street" is a very famous street in New Orleans, which is where they go in this episode, but the title is also playing on with Damon's love for bourbon
Ian Somerhalder grew up in a community rather close to New Orleans.
There's a very hidden reference to Pinky and The Brain in this episode.