Upon finding out that Misha would be directing the episode, Jensen Ackles set up cameras and pied Misha in the face twice.
When Crowley tells Dean, "you're sulking like you lost your knufflebunny," he is referencing the children's book "Knuffle Bunny," by Mo Willems. Knuffle Bunny is a toddler's stuffed rabbit that gets lost at the laundromat.
Sam poses as Agent Leiter. Felix Leiter was a CIA agent in the James Bond novels and movies.
Crowley asks Dean, "You just want to touch that precious again, don't you?" Gollum calls the ring "precious" in J.R.R. Tolkien's The Hobbit and The Lord of the Rings Trilogy.