In 1938, 49 years after JoJo's death, his compatriots Speedwagon and Straizo travel to Mexico, where they discover an underground room filled with masks and a petrified body believed to be the one who created them. Straizo betrays Speedwagon by using one of the masks to become a vampire. Meanwhile, in New York, JoJo's grandson, also nicknamed JoJo, uses the Ripple to save a young pickpocket named Smokey Brown from corrupt policemen. Smokey is taken in by Erina, while Straizo confronts JoJo.