Jesse Tyler Ferguson and Andrea Anders were on the TV show The Class together playing former elementary school classmates who reconnect as adults and become friends.
Jesse Tyler Ferguson (Mitch) and guest star Tyne Daly (Mrs. Plank) are both alumni of The American Musical and Dramatic Academy (AMDA) in New York City.
The episode is titled after the theme song "Won't You Be My Neighbor" from the children's television show Mister Rogers Neighborhood (1968-2001).
Lilly is seen playing in her room with another little girl that is in her class. The little girl is played by actress Raegan Revard who would later play Sheldon Cooper's twin sister Missy in Young Sheldon.
After Claire licks Luke's face Haley mentions they ran out of peanut butter. They must have gotten more because a few scenes later Haley walks behind the couch eating some straight out of the jar.