The title of this episode, 'Do You Remember the First Time?,' comes from a 1994 song by the band Pulp.
In this episode Caroline becomes the fourth character to appear for the 100th time after Elena, Stefan and Damon did last season.
The song "Belong" by the Cary Brothers is played while Damon and Elena are dancing, (keeping in mind Elena doesn't remember their relationship) which is the same song played while Elena confessed her love for Damon. Coincidence? I think not.
Caroline refers to Liam as McDreamy, which was the fan nickname of a doctor on Grey's Anatomy.