The title is likely based on the Werther Effect. The Werther Effect is a sociological term for when there are numerous copycat suicides after a highly publicized suicide, based on Goethe's novel The Sorrows of Young Werther.
The 1973 mother tells her daughter to help with housework and, "please, none of your Betty Friedan stuff". In 1963 Betty Friedan published "The Feminine Mystique", a book arguing that some women are not satisfied with the housewife-mother life of only cooking, grocery shopping, cleaning, raising children, and pleasing her husband. Friedan's radical notion was that some women wanted college degrees and careers, had political opinions maybe even aspirations, and could function (despite their shocking lack of penises) in the world of business.
General background on blood. Someone Sam's size would have at least 16 pints of blood. Tolerance varies, but generally a healthy person can lose 15% of their blood with minimal symptoms; that means Sam could lose 2.5 pints, over a quart, and still function normally. Over 20% loss and you generally start getting a bit light headed; at 30% loss you are in trouble, confused and weak. For Sam 30% would be at least 5 pints, over a half gallon.
When introducing himself to Suzie as a member of the neighborhood watch, Dean uses the alias Dwight Twilley. Twilley was the lead singer of the successful 70's pop/rock group Dwight Twilley Band.
This episode features guest appearances by Kavan Smith and Ty Olsson. Both actors played the same role of the AI robot Andy at different times on the show Eureka (2006). As Andy was a robot, he could be re-skinned with a different appearance, explaining the change in actors.