Dean says: "We're not trapped out here with you, you're trapped out here with us." This is paraphrasing a line by the character Rorschach from The Watchmen comic. It's also a paraphrasing from a line in Rambo: First Blood; that this episode is named after.
Crowley says, "In the immortal words of Lawrence Tureaud, 'I pity the fool'." Lawrence Tureaud is Mr T's real name.
Sam and Dean don't speak until about 23 minutes in.
This is the show's 250th episode.
Dean says, "What we've got here is a failure to communicate." This is a quotation from the 1967 film Cool Hand Luke as well as the opening of the song Civil War by Guns 'N Roses.