In the teaser released in August 2015, Meg Turney plays a CIA agent. Between the release of the teaser and the filming of the series, Turney left Rooster Teeth. Her role was filled by Ashley Jenkins.
Geoff Ramsey had previously stated that he didn't want to be involved with non-Achievement Hunter-related Rooster Teeth productions (presumably excluding "Red vs. Blue"), so his appearance in the teaser for The Eleven Little Roosters (2017) in August 2015 created a major buzz. It turned out that Josh Flanagan had told Ramsey that the teaser was just a teaser thrown together at the last minute and not an indication of actual casting, but when the time came to make the series, Flanagan cast Ramsey anyway.
Successor to the previous Rooster Teeth show "Ten Little Roosters"
In episode 3, Marquis is reading a part of the script of an episode in RWBY Volume 4.
Most of the series is filmed in Austin, Texas.