"Scream & Shout" is an upbeat dance-pop song; its lyrics are about having a good time on a night out.
The song was a commercial success worldwide, topping the charts in over 24 countries and reached the top ten in Australia, Sweden, and South Korea.
In the United States, the song peaked at number three on the Billboard Hot 100 and became the first number one song of the newly established Dance/Electronic Songs chart.
In the United Kingdom, "Scream & Shout" became will.i.am's second consecutive number one single, Spears' sixth number one and her first chart-topper since "Everytime."
An accompanying music video directed by Ben Mor was shot in October 2012, and premiered in the U.S. during a live episode of The X Factor on November 28.