"Take me home..." Along a lonely California highway, a mysterious woman in white lures men to their deaths - a terrifying phenomenon that may be the sisters' first clue to their father's whereabouts.
Deep in the Colorado woods, deep in horror. Sam and Deana's search for their father - and for the evil power that killed Jacob - leads to the blood-soaked path of a Wendigo, a cannibal spirit of Native American lore.
Is a series of drownings in a Wisconsin lake the work of a vengeful spirit? A young eyewitness, traumatized into silence by the shock he experienced, may have the power to prophesy the next drowning.
A plane reservation is a ticket to terror when a phantom traveler forces a jet into a crash landing. Knowing the phantom is on another flight, Sam and Deana board to attempt an in-air exorcism.
"Bloody Mary, Bloody Mary, Bloody Mary." An incantation uttered during a game of truth or dare unleashes a ghoul who "lives" in mirrors - and kills by gouging out the eyes of her prey.
A demonic shapeshifter adopts the likeness of Sam's college buddy to commit a gruesome murder. When the sisters investigate, the being "borrows" Deana's form to continue its killing spree.
In a quiet Iowa college town, a minister prays to protect his parishioners' children. But another minister - a two-centuries-old madman with a hook for a hand - wants them terrified, slashed, and dead.
After a construction worker is killed by insects burrowing into his brain, the sisters investigate a town's history and find that a new housing development is being built on sacred Native American land - with a curse attached.
When Sam starts to have nightmares about their old home, she and Deana head back to Kansas. They soon discover that the new owners of their old house are being plagued by a malevolent entity. Could it be the same thing that killed their mother many years earlier?
Witness the miracle: Faith healer Roy LeGrange cures Deana after an accident leaves her near death. Witness the terror: For every life LeGrange saves, another life must end.
The devil's down in Dixie - and he's driving one scary truck. Sam and Deana investigate when something wheeled, metallic, and evil forces a series of African American drivers off the road to their deaths.
The sisters pose as nuns to gather information at a house visited by sudden death - a death Sam saw in a dream. But precognition may be just the start of preternatural powers Sam suddenly possesses.
A nice decoration for the wall. A backwoods family of hunters likes to stuff and mount their kill as trophies. Only they hunt humans - and they've got Sam.
In Chicago, Sam has the luck to run into Morgan, the girl she met weeks earlier at an Indiana bus stop. But it may be bad luck, especially if Morgan is connected to a demon wreaking death on the Windy City.
Get the hell out of Hell House. Sam and Deana defy a homicidal spirit, but their efforts are encumbered by a pair of goofball paranormal investigators who hope ghost busting gets them girls.
"Thy angels watch me through the night, and keep me safe till morning light." A little girl's prayers are no match for a shtriga, a powerful witch with terrifying ties to the Winchester sisters' childhood.
After an aging hunter falls prey to the vampires he thought he had long ago destroyed, John Winchester joins his daughters to battle the bloodsuckers - and retrieve an unearthly gun they possess.
Morgan's back. And she wants that gun. So she starts killing John's old friends one by one until he agrees to hand over the weapon - even if it means leaving his daughters alone to battle the demon that killed their mother.
Feels like we're running out of time. With a terrifying exorcism, warfare with a pack of demons, and a shocking double-twist story line, the season finale never lets up.