In 2002, US cable television network VH1 named "She Blinded Me with Science" No. 20 on its list of the "100 Greatest One-hit Wonders".
The song was used in the video game Metal Gear Solid V: The Phantom Pain.
The song was sampled by Mobb Deep in their song "Got It Twisted".
In 2006, VH1 placed it at No. 76 on their list of "Greatest Songs of the '80s".
In 2009, it ranked No. 13 on VH1's 100 Greatest One Hit Wonders of the 80s.