- In 1995, Duffy was diagnosed with a rare form of the disease sarcoidosis called neurosarcoidosis. Her brain and spinal cord were affected, leaving her partially paralyzed. She wrote about her affliction in the humorous 2000 autobiography Model Patient: My Life as an Incurable Wise-Ass. In November 2017 she celebrated the publication of her second book, Backbone: Living with Chronic Pain without Turning into One where she wrote about battling with sarcoidosis for two decades. For Duffy, who can usually only get up three days a week, writing has served as a form of therapy. She hopes that her words will help the many others who also deal with chronic pain.
- In 1995 she was diagnosed with neurosarcoidosis, a rare incurable disease that attacks the central nervous system.
- At age 27 she began modeling and appearing in television commercials, then became an VJ for MTV in 1991.
- Graduated from Park Ridge High School, Park Ridge, New Jersey in 1979, and was a classmate of actor James Gandolfini.
- Owns a farm in Connecticut.
- In 2000 her book "Model Patient: My Life As an Incureable Wise-Ass" was published.
- Received a bachelor's degree in Recreational Therapy from the University of Colorado.
- Is of Irish ancestry.
- Has a son, Jack Lambros (b. 2003), with her husband John Lambros.
- Her son, Jack has appeared on the cover of "Parents" magazine.
- Gave her son Jack the nickname "Lefty".
- Husband, John Lambros is an investment banker, born 1966.
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