I acknowledge that I am a history geek, but even if I wasn't, I would still love this show! Rick Green had the excellent idea of making history fun for all those who hate it, and even better for those who love it. While knowledge of the event in question is certainly helpful, it isn't necessary to enjoy the show and understand the jokes - Rick Green explains the event periodically throughout the show. However, without any clue of the context of the episode (Middle Ages vs. Mesopotamia, for example), it would probably be difficult to know what they're talking about.
I highly recommend this to my fellow nerds (I know you're out there.)
I highly recommend this to my fellow nerds (I know you're out there.)