When all the character head off to a conference where they will be presenting, the sparks start to fly. Howard's insecurities kick in and that ticks Bernadette off. Amy is a maniac in bed and drives Penny out. She heads to Leonard. You get the idea. It's very Marx Brothers in its plotting. Much of it is hilarious as everyone bickers with everyone else. Of course, Sheldon with his insistence on order drivers everyone crazy.