Jerome is a day in the life of a dreamer. Wade Hampton has found himself trapped by responsibility and lack of understanding by those closest to him. As a result, Wade simply leaves his old life with the idea of fulfilling a repressed dream of becoming an artist in Jerome, Arizona, a town he knows only through a postcard given to him years earlier by a co-worker. Naturally, an action as extreme as this is not without consequences. On his way, Wade meets Jane, a road hard, enigmatic drifter who lives the life of total freedom he has longed for. As the two speed farther and farther across the scorching Arizona desert, events snowball into an unforeseen crisis forcing Wade to confront realities he never could have imagined only hours earlier.