Cameras capture the staff at work; Papandrao is worried that Ehrlich won't take her news so well; a man comes back to St. Eligius for an unusual procedure.
Siblings have different reactions to the possibility of having a genetic disease; Luther and Auschlander have a shot at performance art; Rosenthal's drug abuse worsens.
Craig and Gideon are both affected by death; Ehrlich is too busy with his work to spend time with Papandrao; Rosenthal feels pressure under visual scrutiny; Luther shares his thoughts on size with a big man.
Papandrao and Ehrlich share a loss; a pair of punks defend one's right to die; mystery surrounds a man who keeps getting blackouts; Craig learns how the mighty are fallen.
Friends gather to celebrate Westphall's birthday in New Hampshire, while Ellen, Craig and Lizzie question all the decisions they've made in their lives.
Surgeons are forced to work nude during an OR-infection study; a visitor lifts Auschlander's spirits; a dumpster dweller protests hospital waste; Morrison and Novino fight an infection in the ICU.
Ehrlich verbally assaults Craig; Griffin fails as a spiritual counselor; Elliot undergoes surgery; Rosenthal enters family therapy with little support; Gideon is made the victim of another high-tech innovation.
Craig returns to the hospital, while Rosenthal wonders if she can return to work as well; Brett Johnston's parents pay him a visit; Auschlander is asked to be a best man.
A fire starts at the Doctor of the Year dinner; Papandrao and her in-laws look for Ehrlich; Chandler is in for a surprise; Fiscus tries to figure out how to tell his plans to his mother; Wade is upset by her patient's bickering parents.
Third year doctors end their residencies. Auschlander tries to keep the hospital open but complications arise. Griffin places his trust in God. Ehrlich comes back from a soul searching surf safari. Ellen is offered a job in Cleveland.