Agent Garett and Triplett have returned to assist Coulson's team hunt down S.H.I.E.L.D.'s devious nemesis--the Clairvoyant. But will Deathlok kill them all to guard his master's identity?
With Colonel Glenn Talbot now on their trail, Coulson and his team seek refuge in the last place anyone would look, where they begin to uncover S.H.I.E.L.D.'S most dangerous secrets -- secrets that could destroy them all.
When May gets kidnapped, Hydra sends out an impersonator to lure Coulson into a trap. Fitz tries to find the confidence to join the rest of the team in their social activities.
The world turns against S.H.I.E.L.D. when Hydra impersonates them to attack The United Nations, and an unexpected enemy leads the charge to bring about their downfall.
A mysterious man is killing off former S.H.I.E.L.D. agents and carving the same markings as Coulson. Coulson tries to track him down. Meanwhile, May leads a team on a manhunt for Ward.
Coulson and team find themselves in an epic face-off against Hydra to uncover an ancient secret, while Ward kidnaps his brother, Senator Christian Ward, for a violent trip down memory lane.
While Coulson's team tries to find the entrance to the mysterious alien city, the rest of the agents try to rescue Raina when they find out that Hydra is after her.